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Expression of heterobispecific antibodies by genes transfected into producer hybridoma cells

โœ Scribed by Lenz, Helmut; Weidle, Ulrich H.

Book ID
122421254
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
701 KB
Volume
87
Category
Article
ISSN
0378-1119

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The presence of a highly purified recombinant interleukin-2 (rIL-2) increased the production of immunoglobulin (IgM or IgG) by human-human hybridomas to 1.5-2.0 times the production by untreated cells. However, these cells did not react with anti-Tac (IL-2 receptor o0 antibody. To enhance the respon