The c-met proto-oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor (HGF), a potent mitogen and motogen for epithelial cells. Because of its profound effects on cell growth and motility, HGF may be important in the development of cancer metastases in hepatocellular carcinoma (
Expression of hepatocyte growth factor (HGF) and its receptor (MET) in medullary carcinoma of the thyroid
β Scribed by Mauro Papotti; Martina Olivero; Marco Volante; Francesco Negro; Maria Prat; Paolo M. Comoglio; Maria Flavia DiRenzo
- Book ID
- 111638349
- Publisher
- Springer US
- Year
- 2000
- Tongue
- English
- Weight
- 522 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1046-3976
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mal and malignant epithelial cells and several other cell The c-met proto-oncogene encodes the tyrosine kinase types, including endothelial cells and melanocytes. 4,5 receptor for hepatocyte growth factor (HGF), a potent It has been reported that the expression of c-Met is enmitogen and motogen for
The present study has investigated the functional role of the Met receptor in primary cultures of 20 papillary carcinomas and of normal thyroid cells obtained from the same patients. Normal and tumour cells grew as adherent cells, formed a confluent monolayer after 10-20 days, had epithelial morphol
Paraffin sections from 29 lung carcinomas (28 primary and 1 metastatic) and 9 pleural malignant mesotheliomas were immunostained with antisera to human hepatocyte growth factorlscatter factor (HGFISF) and its receptor, met. For HGFISF, immunoreactivity was demonstrated in all 9 mesotheliomas, 9 of 1