Hepatocyte growth factor (HGF) and its receptor c-met are present in several human tissues but their expression in mesothelial cells has not been examined. In this study, we have investigated the expression of HGF and c-met in normal human mesothelial cells and 11 human malignant mesothelioma cell l
Expression of c-Met receptor and hepatocyte growth factor/scatter factor in synovial sarcoma and epithelioid sarcoma
✍ Scribed by C. Kuhnen; Edina Tolnay; Hans Ulrich Steinau; Bruno Voss; Klaus-Michael Müller
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 813 KB
- Volume
- 432
- Category
- Article
- ISSN
- 1432-2307
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Paraffin sections from 29 lung carcinomas (28 primary and 1 metastatic) and 9 pleural malignant mesotheliomas were immunostained with antisera to human hepatocyte growth factorlscatter factor (HGFISF) and its receptor, met. For HGFISF, immunoreactivity was demonstrated in all 9 mesotheliomas, 9 of 1
The c-met proto-oncogene encodes the tyrosine kinase receptor for hepatocyte growth factor (HGF), a potent mitogen and motogen for epithelial cells. Because of its profound effects on cell growth and motility, HGF may be important in the development of cancer metastases in hepatocellular carcinoma (
## Abstract ## BACKGROUND. Hepatocyte growth factor (HGF) is a multipotent cytokine that is mediated by its receptor, c‐MET. HGF/c‐MET contributes to tumor progression in many human malignancies; however, HGF/c‐MET is inversely correlated with aggressive biologic behavior in other cancers. Convers