## Abstract Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional growth factor that is involved in invasive growth of tumor cells __via__ its receptor MET, a protein product of __cβmet__ protoβoncogene. HGF activator (HGFA) is a serine proteinase responsible for the activation of p
Roles of hepatocyte growth factor (HGF) activator and HGF activator inhibitor in the pericellular activation of HGF/scatter factor
β Scribed by Hiroaki Kataoka; Shiro Miyata; Shunro Uchinokura; Hiroshi Itoh
- Book ID
- 110431183
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 724 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0167-7659
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Expression of c-Met, the receptor for hepatocyte growth factor (HGF). and the biological roles of HGF were examined in cultured human glioma cells. All of the 5 glioma cell lines examined expressed c-Met protein as well as the c-met gene. Expression of the c-met gene was also confirmed in a glioblas
## Abstract Hepatocyte growth factor (HGF) plays a plethora of roles in cancer metastasis and tumour growth. The interaction between tumour cells and their surrounding stromal environment is a crucial factor regulating tumour invasion and metastasis. Stromal fibroblasts are the main source of HGF i
The present study has investigated the functional role of the Met receptor in primary cultures of 20 papillary carcinomas and of normal thyroid cells obtained from the same patients. Normal and tumour cells grew as adherent cells, formed a confluent monolayer after 10-20 days, had epithelial morphol