Expression of connective tissue growth factor in renal tubulointerstitial fibrosis in rats and its pathogenic role
β Scribed by Zhang Chun; Zhu Zhonghua; Liu Jianshe; Yang Xiao; Fu Ling; Deng Anguo; Meng Xianfang
- Book ID
- 105645515
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- Chinese
- Weight
- 579 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0510-9752
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Connective tissue growth factor (CTGF) stimulates in vitro fibroblast proliferation and extracellular matrix synthesis. The aim of this study was to assess the role of CTGF in liver fibrogenesis. CTGF expression was investigated both at the protein and mRNA level in biopsies of chronic liver disease
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## Abstract ## Background Connective tissue growth factor (CTGF) is a highly profibrogenic molecule implicated in hepatic fibrogenesis. Small interfering RNA (siRNA) is an effective tool to silence gene expression postβtranscriptionally. Therefore, we conducted an investigation to determine if int