Expression of an immunoglobulin VH gene in natural anti-hapten antibodies
✍ Scribed by O. Mäkelä; Thereza Imanishi
- Publisher
- John Wiley and Sons
- Year
- 1975
- Tongue
- English
- Weight
- 401 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0014-2980
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## Abstract In an earlier study we found that some mouse strains, including the C57BL/6, produced irregular IgG anti‐(4‐hydroxy‐3‐nitrophenyl)acetyl (NP) antibodies to protein conjugates of this hapten. This antibody had heteroclitic fine specificity and a characteristic isoelectric focusing patter
The tat regulatory protein of HIV-1 was expressed as a fusion protein in E. coli and used as antigen to detect antibodies against HIV-tat (anti-tat) in the serum of HIV-1 infected children and adults. HIV-1-infected children showed a higher frequency (55%) of anti-tat than HIV-1-infected adults (36%