Expression of a mouse Ig V gene in antibodies of three immunoglobulin classes

✍ Scribed by Thereza Imanishi; M. Hurme; Heikki Sarvas; O. Mäkelä

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 509 KB
• Volume: 5
• Category: Article
• ISSN: 0014-2980
• DOI: 10.1002/eji.1830050309

✦ Synopsis

Abstract

In an earlier study we found that some mouse strains, including the C57BL/6, produced irregular IgG anti‐(4‐hydroxy‐3‐nitrophenyl)acetyl (NP) antibodies to protein conjugates of this hapten. This antibody had heteroclitic fine specificity and a characteristic isoelectric focusing pattern. Breeding studies suggested that these qualities of the C57BL/6 anti‐NP were controlled by a V gene of the heavy chain. We have now found that this V gene is expressed in anti‐NP antibodies and plaque‐forming cells of all major immunoglobulin classes: IgG, IgA and IgM.