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Expression of a Dominant Negative Inhibitor of NF-κB Protects MIN6 β-Cells from Cytokine-Induced Apoptosis

✍ Scribed by Marshall S. Baker; Xiaojuan Chen; Xiao Chun Cao; Dixon B. Kaufman


Book ID
115636364
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
386 KB
Volume
97
Category
Article
ISSN
0022-4804

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Ataxia telangiectasia (AT) cells exhibit greater levels of apoptosis than normal fibroblasts following exposure to X-rays or radiomimetic drugs. In this study, we investigated apoptosis in AT cells whose radiation sensitivity has been altered by transfection with a cDNA expressing truncated IB-␣ (⌬I