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NFκB mediates LPS-induced expression of IL-6 and ICAM-1 in activated hepatic stellate cells, a process blocked by proteasome inhibitors

✍ Scribed by C. Hellerbrand; C. Jobin; L.L. Licato; R.B. Sartor; D.A. Brenner

Book ID
118568167
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
174 KB
Volume
28
Category
Article
ISSN
0168-8278

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Inhibition of NFκB in activated rat hepatic stellate cells by proteasome inhibitors and an IκB super-repressor
✍ Claus Hellerbrand; Christian Jobin; Yuji Iimuro; Laura Licato; R. Balfour Sartor 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 500 KB

The hepatic stellate cell (HSC), following a fibrogenic stimulus, is transformed from a quiescent to an activated cell. Cytokines induce NFB activity in activated but not in quiescent HSCs with subsequent expression of NFBresponsive genes, such as intercellular adhesion molecule (ICAM)-1 and interle