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Expression of a constitutively active form of phosphatidylinositol 3-kinase inhibits the induction of nitric oxide synthase in human astrocytes

✍ Scribed by Kalipada Pahan; Xiaojuan Liu; Charles Wood; John R. Raymond

Book ID: 117101770
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 244 KB
Volume: 472
Category: Article
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(00)01465-4

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## Abstract Excitotoxicity and cell death induced by glutamate are involved in many neurodegenerative disorders. We have previously demonstrated that excitotoxicity induced by millimolar concentrations of glutamate in hippocampal slices involves apoptotic features and glutamate‐induced glutamate re