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Expression of Constitutively Active Phosphatidylinositol 3-Kinase Inhibits Activation of Caspase 3 and Apoptosis of Cardiac Muscle Cells

✍ Scribed by Wu, W.; Lee, W.-L.; Wu, Y. Y.; Chen, D.; Liu, T.-J.; Jang, A.; Sharma, P. M.; Wang, P. H.


Book ID
125331316
Publisher
The American Society for Biochemistry and Molecular Biology
Year
2000
Tongue
English
Weight
645 KB
Volume
275
Category
Article
ISSN
0021-9258

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## Abstract Increased expression of plasminogen activator inhibitor type 1 (PAI‐1) is associated with decreased apoptosis of neoplastic cells. We sought to determine whether PAI‐1 alters apoptosis in vascular smooth muscle cells (VSMC) and, if so, by what mechanisms. A twofold increase in the expre