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Expression of 11β-hydroxysteroid dehydrogenase isoforms in canine adrenal glands treated with trilostane

✍ Scribed by Teshima, Takahiro; Matsumoto, Hirotaka; Kumagai, Takayuki; Kurano, Mai; Koyama, Hidekazu


Book ID
121758009
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
359 KB
Volume
200
Category
Article
ISSN
1090-0233

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## Abstract Renal 11β‐hydroxysteroid dehydrogenase 2 (HSD2) catalyzes the conversion of active glucocorticoids to inert 11β‐keto compounds, thereby preventing the illicit binding of these hormones to mineralocorticoid receptors (MRs) and, thus, conferring aldosterone specificity. Absence or inhibit