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Expression and mutation of p53 gene in the lung of mice intratracheal injected with crystalline silica

✍ Scribed by Yoko Ishihara; Hiroko Iijima; Kenichi Matsunaga; Toshihiko Fukushima; Toshio Nishikawa; Seiichi Takenoshita


Book ID
117467179
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
97 KB
Volume
177
Category
Article
ISSN
0304-3835

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Ki-ras gene mutations and absence of p53
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Ki-ras and p53 genes are involved in human lung carcinogenesis; however, the role of these genes in experimental lung tumors is not well known. In our study, the CBA/J mouse strain was used to investigate the presence of Ki-ras and p53 alterations in lung carcinogenesis of spontaneous tumors and tum