Expression of alternatively spliced mdm2
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Alison Kraus; Frauke Neff; Moira Behn; Marcus Schuermann; Kristin Muenkel; Juerg
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Article
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1999
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John Wiley and Sons
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French
โ 69 KB
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A puzzling finding in various human tumors, including glioblastoma multiforme (GBM), is the stabilization of wildtype (wt) p53 protein. The biological significance of this phenomenon and the mechanism by which it occurs are unexplained. Recent reports have revealed that mdm2 exerts its negative regu