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Heterogeneous distribution of P53 immunoreactivity in human lung adenocarcinoma correlates with MDM2 protein expression, rather than with P53 gene mutation

โœ Scribed by Takaomi Koga; Shuichi Hashimoto; Kenji Sugio; Ichiro Yoshino; Kazunori Nakagawa; Yoshikazu Yonemitsu; Keizo Sugimachi; Katsuo Sueishi


Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
538 KB
Volume
95
Category
Article
ISSN
0020-7136

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A puzzling finding in various human tumors, including glioblastoma multiforme (GBM), is the stabilization of wildtype (wt) p53 protein. The biological significance of this phenomenon and the mechanism by which it occurs are unexplained. Recent reports have revealed that mdm2 exerts its negative regu