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Exploring the Function of Titin Kinase by Mechanical Single-Molecule Pump-And-Probe

✍ Scribed by Puchner, Elias M.; Gaub, Hermann E.

Book ID
122188967
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
51 KB
Volume
98
Category
Article
ISSN
0006-3495

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Inside Cover: Exploring the Conformation
Inside Cover: Exploring the Conformation-Regulated Function of Titin Kinase by Mechanical Pump and Probe Experiments with Single Molecules (Angew. Chem. Int. Ed. 6/2010)
✍ Eliasβ€…M. Puchner; Hermannβ€…E. Gaub πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 389 KB

The molecular-force sensor titin kinase (TK) is embedded in the M-band structure of the sarcomere at an ideal position to sense force imbalances. H. E. Gaub and E. M. Puchner demonstrate in their Communication on page 1147 ff. a new AFM-based single-molecule pump-and-probe protocol to mechanically p