Exploring the Conformation-Regulated Function of Titin Kinase by Mechanical Pump and Probe Experiments with Single Molecules

Inside Cover: Exploring the Conformation

Inside Cover: Exploring the Conformation-Regulated Function of Titin Kinase by Mechanical Pump and Probe Experiments with Single Molecules (Angew. Chem. Int. Ed. 6/2010)

✍ Elias M. Puchner; Hermann E. Gaub 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 389 KB

The molecular-force sensor titin kinase (TK) is embedded in the M-band structure of the sarcomere at an ideal position to sense force imbalances. H. E. Gaub and E. M. Puchner demonstrate in their Communication on page 1147 ff. a new AFM-based single-molecule pump-and-probe protocol to mechanically p