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Exploring phosphatidylinositol 5-phosphate 4-kinase function

✍ Scribed by Bulley, Simon J.; Clarke, Jonathan H.; Droubi, Alaa; Giudici, Maria-Luisa; Irvine, Robin F.

Book ID: 126653477
Publisher: Elsevier
Year: 2015
Tongue: English
Weight: 320 KB
Volume: 57
Category: Article
ISSN: 2212-4926
DOI: 10.1016/j.jbior.2014.09.007

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## Abstract Type I phosphatidylinositol 4‐phosphate 5‐kinase (PI4P5K) catalyzes the phosphorylation of phosphatidylinositol 4 phosphate [PI(4)P] at carbon 5, producing phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2]. Phosphatidic acid (PA) activates PI4P5K in vitro and plays a central role in the