Localization, regulation and function of Type II phosphatidylinositol 5-phosphate 4-kinases
โ Scribed by Jonathan H. Clarke; Michael Wang; Robin F. Irvine
- Book ID
- 113418989
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 474 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0065-2571
No coin nor oath required. For personal study only.
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## Abstract The type I phosphatidylinositol 4โphosphate 5โkinases (PI4P5K) phosphorylate phosphatidylinositol 4โphosphate [PI(4)P] to produce phosphatidylinositol 4,5โbisphosphate [PI(4,5)P~2~]. PI(4,5)P~2~ has been implicated in signal transduction, receptor mediated endocytosis, vesicle trafficki
## Abstract Type I phosphatidylinositol 4โphosphate 5โkinase (PI4P5K) catalyzes the phosphorylation of phosphatidylinositol 4 phosphate [PI(4)P] at carbon 5, producing phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2]. Phosphatidic acid (PA) activates PI4P5K in vitro and plays a central role in the