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Exploratory data from complete genomes of familial alzheimer disease age-at-onset outliers

✍ Scribed by Matthew A. Lalli; Gloria Garcia; Lucia Madrigal; Mauricio Arcos-Burgos; Mary Luz Arcila; Kenneth S. Kosik; Francisco Lopera

Book ID
115556417
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
232 KB
Volume
33
Category
Article
ISSN
1059-7794

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## Abstract We performed linkage analysis for age at onset (AAO) in the total Alzheimer's disease (AD) NIMH sample (N = 437 families). Families were subset as late‐onset (320 families, AAO β‰₯65) and early/mixed (117 families, at least 1 member with 50< AAO <65). Treating AAO as a censored trait, we