## Center, Waslrington, DC 20012 A biodegradable copolymer of 50 polylac-tide50 polyglycolide was prepared for implantation into experimentally created os- seous defects in the tibias of 25 rats. Similarly prepared defects were made in the humeri of the same rats and these defects did not receive
Experimental study of the osteogenic capacity of periosteal allografts: A preliminary report
β Scribed by Dr. Jian Yin Liu; Dan Wang; Hsu Hsi Cheng
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 572 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0738-1085
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β¦ Synopsis
Abstract
A total of 16 rabbits were used in this investigation. Beijing longβeared white rabbits served as donors and immunologically incompatible Chinchilla rabbits as recipients. Periosteal flaps were stripped from the femurs of 8 donor rabbits and implanted into the muscles of both thighs of 8 recipients. Revascularization of the grafts was done only on the left side. Immunosuppressants were administered orally beginning the day of surgery. The animals were observed for 1β4 months. A series of radiography, histomorphology, fluochrome labelling, and electron microscopic examinations were performed. The results demonstrated that all of the revascularized periosteal allografts had new bone formation (8/8), while the nonβrevascularized periosteal allografts had none (0/8). The difference in the rate of new bone formation between the two groups was statistically significant. Β© 1994 WileyβLiss, Inc.
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