Preliminary report on the osteogenic potential of a biodegradable copolymer of polyactide (PLA) and polyglycolide (PGA)
✍ Scribed by Hollinger, Jeffrey O.
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 900 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
Center, Waslrington, DC 20012
A biodegradable copolymer of 50 polylac-tide50 polyglycolide was prepared for implantation into experimentally created os- seous defects in the tibias of 25 rats. Similarly prepared defects were made in the humeri of the same rats and these defects did not receive copolymer implants. Upon sacrifice, both the implant treated and untreated sites of the experimentally produced osseous defects were evaluated by gross appearance and by histomorphometric examination using a Zeiss Videoplan Image Analysis System with Osteoplan (version 4.1). The animals were evaiuated in groups of five at 7, 14,21,28, and 42 days. When compared with bony defects that were not treated with the biocompatible, biodegradable copolymer implant, the implant sites displayed an accelerated rate of healing at 7, 14, 21, and 28 days (p < 0.001). A similar healing response rate, however, was observed at 42 days (p < 0.25-0.1). No adverse host tissue responses were observed histologically.