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Experimental models to evaluate the role of P-glycoprotein in the blood–brain tumor barrier

✍ Scribed by Olaf van Tellingen; E. Marleen Kemper; Tessa Buckle


Book ID
116537601
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
645 KB
Volume
1277
Category
Article
ISSN
0531-5131

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This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded