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Challenges of UsingIn VitroData for Modeling P-Glycoprotein Efflux in the Blood-Brain Barrier

✍ Scribed by Sjöstedt, Noora; Kortejärvi, Hanna; Kidron, Heidi; Vellonen, Kati-Sisko; Urtti, Arto; Yliperttula, Marjo


Book ID
120511767
Publisher
Springer US
Year
2013
Tongue
English
Weight
552 KB
Volume
31
Category
Article
ISSN
0724-8741

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This article describes the experimental set-up and pharmacokinetic modeling of P-glycoprotein function in the rat blood-brain barrier using [ 11 C]verapamil as the substrate and cyclosporin A as an inhibitor of P-gp. [ 11 C]verapamil was administered to rats as an i.v. bolus dose followed by graded