Experimental investigation of the role of endothelin-1 in idiopathic portal hypertension
β Scribed by Emi Yamaguchi; Akira Yamanoi; Takashi Ono; Naofumi Nagasue
- Book ID
- 108951275
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 173 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0815-9319
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Portal hypertension (PHT) is characterized by increased portal pressure caused in part by a reduction in mesenteric vascular resistance. The aim of this study was to evaluate the role of endothelin (ET) and specific ET receptors in maintaining the vasculopathy of PHT. PHT was created in Sprague-Dawl
Factors that increase resistance to blood flow through the hepatic sinusoids when portal hypertension occurs in the absence of significant hepatic fibrosis are not completely understood. Experiments were designed to test the hypothesis that endothelin-1 (ET-1) is one of the humoral factors that incr
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