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Experience with a 82Sr/82Rb generator for clinical use

โœ Scribed by M.J. Kensett; P.L. Horlock; S.L. Waters; D.M. Bateman

Publisher
Elsevier Science
Year
1987
Weight
465 KB
Volume
38
Category
Article
ISSN
0883-2889

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โœฆ Synopsis

A 82Sr/82Rb generator system is described which is shown to be suitable for continuous intravenous infusion in man. The breakthrough of the 82Sr parent has been closely monitored and remained less than 18.5 Bq mL-1 of infusate. A method using a 0.05% solution of sodium hypochlorite to disinfect the generator resulted in a sterile and pyrogen free eluate. Recommendations are made for the setting up of the generator to ensure the maintenance of its pharmaceutical integrity.

๐Ÿ“œ SIMILAR VOLUMES

Model for 82Sr/82Rb generator elution pr
Model for 82Sr/82Rb generator elution profiles: A secondary approach to radioassay/dosimetry
โœ Vijay Dhawan ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› Elsevier Science โš– 567 KB

Static (dose calibrator) assays of 82Rb bolus yield erroneous estimates of administered activity by ignoring the asymmetric output of 82Sr/82Rb generators. Though on-line monitoring of elution profile improves accuracy for quantitative purposes, it requires an elaborately shielded detector and assoc