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Expeditious formal synthesis of (±)-epibatidine using diastereoselective bromohydroxylation of aminocyclohexene derivatives

✍ Scribed by Isabelle Cabanal-Duvillard; Jean-François Berrien; Jacques Royer; Henri-Philippe Husson

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
207 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

Brominalion and bromoh)drox)lalion of oxazolidinones derived from cyclohexadienc have been studied in order to synlhctizc (_+)-cpibatidine 18. Bromohydrox.wlation of compound 2 led to a polyfunctionalized halohydrin lla ~vhich could be furlher c.vclized to azabieyclol2.2. I Iheptan-2one 16 already described as a precursor ofcpibalidine 18.

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