Expedient Synthesis of Highly Substituted Fused Heterocoumarins
✍ Scribed by Sellès, P.; Mueller, U.
- Book ID
- 121423638
- Publisher
- American Chemical Society
- Year
- 2004
- Tongue
- English
- Weight
- 72 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1523-7060
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New tetracyclic 6H-[1]benzopyrano [3,4-e]pyrazolo[1,5-a]pyrimidin-6-ones (4a-e) have been synthesized through the condensation under acidic conditions of [1]benzopyrano [4,3-c][1,5]-benzodiazepin-7(8H)-one (1) and a series of 3,4-disubsituted 5-amino-1H-pyrazoles 3a-e.
Condensation of carboxylic acid esters with organodilithium reagents derived from N-trimethylsilyl-o-toluidine or N-trimethylsilyl-o-ethyl aniline affords substituted indoles. The indole ring system, one of the most prevalent structural subunits in natural products chemistry, has captured the intere