Condensation of carboxylic acid esters with organodilithium reagents derived from N-trimethylsilyl-o-toluidine or N-trimethylsilyl-o-ethyl aniline affords substituted indoles. The indole ring system, one of the most prevalent structural subunits in natural products chemistry, has captured the intere
โฆ LIBER โฆ
An expedient synthesis of substituted guanidines
โ Scribed by Krishnamurthy Ramadas; Natarajan Srinivasan
- Book ID
- 103404991
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 161 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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An efficient method for the solid-phase synthesis of substituted guanidines is presented. A variety of alcohols react with resin-bound N,N'-bis(t-butoxycarbonyl)thiopseudourea under Mitsunobu conditions to give the corresponding alkylated thiopseudoureas. The guanidines are liberated from the resin