Expedient method for the solid-phase synthesis of some 4-substituted-4,5-dihydropyridazin-3(2H)-ones
β Scribed by Gouault, Nicolas; Cupif, Jean-Fran??ois; Amoros, Maryvonne; David, Mich??le
- Book ID
- 121646395
- Publisher
- Royal Society of Chemistry
- Year
- 2002
- Weight
- 155 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1472-7781
- DOI
- 10.1039/B205607K
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π SIMILAR VOLUMES
Reaction of N-aryl substituted maleimides with aliphatic ketazines leads to the formation of 4,5-dihydropyridazin-3(2H)-ones in moderate yields. The reaction proceeds through 1,4-addition of an azine to the maleimide double bond, as confirmed by separation of the corresponding adducts in some cases,
The solid phase synthesis of 2,4,5-trisubstituted thiomorpholin-3-ones is described. Starting from a resin-bound protected cysteine, and employing reductive alkylation and amide formation, thiomoq~holin-3one derivatives have been synthesized through intramolecular thioether formation in good yield a