Expedient Asymmetric Synthesis of All Four Isomers of N,N ‘ -Protected 2,3-Diaminobutanoic Acid
✍ Scribed by Robinson, Andrea J.; Stanislawski, Pauline; Mulholland, Dean; He, Linnan; Li, Hui-Yin
- Book ID
- 126012876
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 59 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
The synthesis of all four individual isomers of 3-methyl-3-(2'-naphthyl)analine was accomplished using asymmetric conjugate 1 A-addition followed by direct or indirect azidation using an Evans-type chiral auxiliary (4-phenyl-2-oxazolidinone).
We have developed methods for the synthesis of the four optically pure isomers of B-methyltryptophan with the 2-mesitylenesulfonyl indole protecting group for peptide synthesis. Starting from 3-indoleacrylic acid, the Bmethyl function was generated by a chiral auxiliary-directed asymmetric conjugate