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Asymmetric Synthesis of All Four Isomers of an Unusual Heterocycle-Containing Amino Acid: 2-Amino-3-furan-2-yl-pentanoic Acid

✍ Scribed by Lei Nie; Rui Yang; Conghai Zhang; Haichuan Yin; Shengjiao Yan; Jun Lin


Book ID
112060455
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
820 KB
Volume
30
Category
Article
ISSN
0256-7660

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Asymmetric Synthesis of an Unusual Amino Acid: Synthesis of Four Isomers of Ξ²-Methyl-3-(2'-naphthyl)alanine. -Using (R)-4phenyloxazolidinone (II) as chiral auxiliary, the synthesis of the optically pure amino acid (VIII) is achieved by diastereoselective methylation followed by indirect azidation a