The synthesis of all four individual isomers of 3-methyl-3-(2'-naphthyl)analine was accomplished using asymmetric conjugate 1 A-addition followed by direct or indirect azidation using an Evans-type chiral auxiliary (4-phenyl-2-oxazolidinone).
β¦ LIBER β¦
Asymmetric Synthesis of All Four Isomers of an Unusual Heterocycle-Containing Amino Acid: 2-Amino-3-furan-2-yl-pentanoic Acid
β Scribed by Lei Nie; Rui Yang; Conghai Zhang; Haichuan Yin; Shengjiao Yan; Jun Lin
- Book ID
- 112060455
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 820 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0256-7660
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Asymmetric Synthesis of an Unusual Amino Acid: Synthesis of Four Isomers of Ξ²-Methyl-3-(2'-naphthyl)alanine. -Using (R)-4phenyloxazolidinone (II) as chiral auxiliary, the synthesis of the optically pure amino acid (VIII) is achieved by diastereoselective methylation followed by indirect azidation a
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