Exercise and the pharmacokinetics of propranolol, verapamil and atenolol
β Scribed by M. A. van Baak; J. M. V. Mooij; P. M. H. Schiffers
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 617 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0031-6970
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## Abstract The lipophilic betaβadrenoreceptor antagonist propranolol and hydrophilic atenolol have been studied to define their pharmacokinetic and pharmacodynamic characteristics in obese patients. A total of 43 subjects were allocated into three study groups: (1) healthy, lean, normolipaemic vol
The influence of endotoxin-induced inflammation was studied on the pharmacokinetics of the enantiomers of the racemic drugs oxprenolol, propranolol, and verapamil in rabbits and dogs. Enantioselective pharmacokinetics were seen for oxprenolol and propranolol in the rabbit and for propranolol and ver
The influence of endotoxin-induced inflammation on the enantioselective phannacokinetics of propranolol, oxprenolol, and verapamil, which bind to a,-acid glycoprotein, was studied in the rat. The racemic mixtures were given orally. In the control animals, for propranolol and oxprenolol, the plasma c