In an earlier paper, positive but nonsignificant lod scores were found in pair-wise linkage tests between multiple endocrine neoplasia type 2A (MEN-2A) and both the haptoglobin (HP) locus on chromosome 16 and group-specific component (GC) locus on chromosome 4. Recently discovered restriction fragme
β¦ LIBER β¦
Exclusion of linkage between the loci for multiple endocrine neoplasia type-2 (MEN-2) and HLA
β Scribed by Nancy E. Simpson; Judy Falk
- Publisher
- Springer
- Year
- 1982
- Tongue
- English
- Weight
- 97 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0340-6717
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Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disease characterized by endocrine tumors of the parathyroids, the pancreatic islets, and the anterior pituitary. The MEN1 gene encodes menin, a nuclear protein interacting with JunD/AP1, Smad3, NFkappaB, and other proteins involved