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Exclusion of linkage between the loci for multiple endocrine neoplasia type-2 (MEN-2) and HLA

✍ Scribed by Nancy E. Simpson; Judy Falk


Publisher
Springer
Year
1982
Tongue
English
Weight
97 KB
Volume
60
Category
Article
ISSN
0340-6717

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In an earlier paper, positive but nonsignificant lod scores were found in pair-wise linkage tests between multiple endocrine neoplasia type 2A (MEN-2A) and both the haptoglobin (HP) locus on chromosome 16 and group-specific component (GC) locus on chromosome 4. Recently discovered restriction fragme

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Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal dominant disease characterized by endocrine tumors of the parathyroids, the pancreatic islets, and the anterior pituitary. The MEN1 gene encodes menin, a nuclear protein interacting with JunD/AP1, Smad3, NFkappaB, and other proteins involved