Progress toward resolving the possible linkage of multiple endocrine neoplasia type 2A to haptoglobin and group-specific loci: Use of restriction fragment length polymorphisms extends exclusion region
✍ Scribed by K. K. Kidd; J. R. Kidd; C. M. Castiglione; A. J. Pakstis; R. S. Sparkes; D. C. Rao
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 403 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0741-0395
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✦ Synopsis
In an earlier paper, positive but nonsignificant lod scores were found in pair-wise linkage tests between multiple endocrine neoplasia type 2A (MEN-2A) and both the haptoglobin (HP) locus on chromosome 16 and group-specific component (GC) locus on chromosome 4. Recently discovered restriction fragment length polymorphisms for HP and for metallothionein 2 processed pseudogene 1 ( M R P I ) near GC have made it possible to carry out a more powerful set of linkage tests with MEN-2A. This paper reports the results of such linkage analyses employing both pair-wise and multipoint tests. Close linkage of HP on chromosome 16 and MEN-2A is excluded. Linkage of MEN-2A on chromosome 4 with GC is excluded on the M E P I side of GC in a 7-centimorgan interval around M72PI.