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Excitatory amino acid antagonists and pentylenetetrazol-induced seizures during ontogenesis

✍ Scribed by Libor Velíšek; Soňa Verešová; Helena Pôbišová; Pavel Mareš

Book ID
105510860
Publisher
Springer
Year
1991
Tongue
English
Weight
594 KB
Volume
104
Category
Article
ISSN
0033-3158

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Administration of 1-methyl-4-phenyl-pyridinium ion (MPP') into the lateral ventricle of mice induced clonic convulsions and lethality in a dose-and agedependent manner. MPP' failed to induce seizures in 4-day-old mice, and the convulsant response to MPP+ was enhanced in aged mice. The seizures trigg