Excision products of immunoglobulin gene rearrangements
β Scribed by Masaaki Toda; Toshiyasu Hirama; Sunao Takeshita; Hideo Yamagishi
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 362 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0165-2478
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We have examined 69 B-cell non-Hodgkin's lymphomas (NHL) for rearrangements of the immunoglobulin (Ig) or Tcell antigen receptor (TCR) genes. The lymphomas were assigned to the categories of the Kiel classification and their B-cell nature was confirmed by immunostaining. Only 2 cases (with CLL) disp
The antigen receptor on B lymphocytes is the product of a series ~of gene rearrangements which ends when a functional receptor gene is assembled. Recent work has shown that the receptor-associated molecules Iga and Igl3 provide the signals that lead to inhibition of further recombination. Furthermor