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Excised damaged base determines the turnover of human N-methylpurine-DNA glycosylase

✍ Scribed by Sanjay Adhikari; Aykut Üren; Rabindra Roy

Book ID
113568118
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
564 KB
Volume
8
Category
Article
ISSN
1568-7864

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## Abstract Primary astrocyte cultures were used to investigate the modulation of DNA repair as a tool for sensitizing astrocytes to genotoxic agents. Base excision repair (BER) is the principal mechanism by which mammalian cells repair alkylation damage to DNA and involves the processing of relati