Exchange of cell-associated β2-microglobulin in mouse chimeras

✍ Scribed by Shoji Kimura; Nobuhiko Tada; Yen Liu-Lam; Ulrich Hämmerling

• Book ID: 104743685
• Publisher: Springer-Verlag
• Year: 1983
• Tongue: English
• Weight: 155 KB
• Volume: 18
• Category: Article
• ISSN: 0093-7711
• DOI: 10.1007/bf00368547

✦ Synopsis

Recent evidence suggests that the Ly-m11 alloantigen (Tada et al. 1980) is an allotypic determinant of mouse beta-2-microglobulin (B2m). In support of this are:

(1) tight genetic linkage between the Ly-mll locus and the locus governing structural polymorphism of B2m (Michaelson 1981, Goding 1981), (2) identical tissue distribution of the two molecules (Tada et al. 1980, Kimura et al. 1981), (3) ability of Ly-mll-specific antibody to precipitate B2m (S. G. Nathenson and N. Tada, unpublished data), and (4) blocking of the interaction of cytotoxic lymphocytes and their target cells (Tomonari et al. 1982). Recently, Margulies and coworkers (1983) provided the direct evidence that Ly-m11 alloantigen was an allotypic determinant of the B2m molecule by transfection of B2m gene into L cells.