Lysine-specific cleavage of β2-microglobulin in amyloid deposits associated with hemodialysis
✍ Scribed by Linke, Reinhold P; Hampl, Hannelore; Lobeck, Hartmut; Ritz, Eberhard; Bommer, Jürgen; Waldherr, Rüdiger; Eulitz, Manfred
- Book ID
- 109881347
- Publisher
- Nature Publishing Group
- Year
- 1989
- Tongue
- English
- Weight
- 667 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0085-2538
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A correlation is demonstrated between chronic hemodialysis using cuprophane membranes (mean duration: 13 years) and pathological fractures (n = 7 in 6 patients) after lytic bone deposits of beta 2-microglobulin amyloid (n = 13 patients). The characteristic symptom complex includes painful impingemen
Among various amyloidogenic proteins, beta(2)-microglobulin (beta2-m) responsible for dialysis-related amyloidosis is a target of extensive study because of its clinical importance and suitable size for examining the formation of amyloid fibrils in comparison with protein folding to the native state