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Examination of Zolpidem effects on AhR- and PXR-dependent expression of drug-metabolizing cytochromes P450 in primary cultures of human hepatocytes

✍ Scribed by Petr Bachleda; Radim Vrzal; Jakub Pivnicka; Boris Cvek; Zdenek Dvorak


Book ID
119381754
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
402 KB
Volume
191
Category
Article
ISSN
0378-4274

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The aim of this study was to test suitable culture conditions for maintaining normal cellular cytoarchitecture and inducibility of P450 enzymes in primary cultures of human hepatocytes by prototypical inducers. The selectivity and sensitivity of a sandwich culture system were determined by treating