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Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes

✍ Scribed by Zdeněk Dvořák; Radim Vrzal; Pavel Štarha; Alena Klanicová; Zdeněk Trávníček

Book ID: 116920153
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 245 KB
Volume: 24
Category: Article
ISSN: 0887-2333
DOI: 10.1016/j.tiv.2009.10.012

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## Abstract Four β‐glycosides of flavonoligan silybin, i.e. silybin β‐galactoside, silybin β‐glucoside, silybin β‐maltoside, silybin β‐lactoside were synthesized in order to improve silybin water solubility and bioavailability (Křen et al., J Chem Soc, Perkin Trans 1, 2467–2474, 1997). The presente