Two children with Ewing's sarcoma developed acute nonlymphocytic leukemia (ANLL) during the course of their illness. One patient developed ANLL after apparently successful treatment of his primary malignancy with radiation therapy and multiagent chernotherapy. In the second patient, acute leukemia d
Ewing's sarcoma t(11;22) in a case of acute nonlymphocytic leukemia
โ Scribed by Jacqueline M. Hawkins; Jeffrey M. Craig; Lorna M. Secker-Walker; H.Grant Prentice; Atul B. Mehta
- Book ID
- 119104856
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 321 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0165-4608
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Fluorescence in situ hybridization (FISH) using chromosome-specific plasmid libraries and chromosome region-specific DNA markers allowed the characterization of a t( 1022; I I ) (p I I .2;q I2;q24) in a Ewing's sarcoma (ES). This study illustrates the usefulness of molecular cytogenetic analysis of
Polymerase chain reaction (PCR)-directed sequence analysis was performed to characterize the genomic and cDNA breakpoint junctions of t( I I ;22) (q24;q 12) translocation in a case of Ewing's sarcoma, in which the EWS gene located on chromosome 22 is rearranged with the FUI gene located on chromosom