Acute nonlymphocytic leukemia developing during the course of Ewing's sarcoma

✍ Scribed by Link, Michael P. ;Donaldson, Sarah S. ;Kempson, Richard L. ;Wilbur, Jordan R. ;Glader, Bertil E.

• Book ID: 102950810
• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 832 KB
• Volume: 12
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/mpo.2950120310

✦ Synopsis

Two children with Ewing's sarcoma developed acute nonlymphocytic leukemia (ANLL) during the course of their illness. One patient developed ANLL after apparently successful treatment of his primary malignancy with radiation therapy and multiagent chernotherapy. In the second patient, acute leukemia developed before the administration of radiotherapy or systemic chemotherapy. The development of secondary ANLL after Ewing's sarcoma has been reported only twice pireviously, most likely representing a therapyinduced complication. The occurrence of ANLL in Patient 2 prior to therapy suggests that these two disorders may have a more than treatment-related association. Close follow-up of long-term survivors of Ewing's sarcoma with surveillance for secondary acute leukemia is advised.