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Molecular cytogenetic analysis of a complex t(10;22;11) translocation in ewing's sarcoma

✍ Scribed by Frank Speleman; Nadine Van Roy; Jules G. Leroy; Anne Marie Dierick; Dirk Uyttendaele; Joop Wiegant

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
492 KB
Volume
4
Category
Article
ISSN
1045-2257

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✦ Synopsis

Fluorescence in situ hybridization (FISH) using chromosome-specific plasmid libraries and chromosome region-specific DNA markers allowed the characterization of a t( 1022; I I ) (p I I .2;q I2;q24) in a Ewing's sarcoma (ES). This study illustrates the usefulness of molecular cytogenetic analysis of ES, especially for determining the localization of the translocated I I q24-25 segment in complex or variant translocations. Genes Chrorn Cancer 4: 188-I 9 I ( / 992).

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