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Evolutionarily Conserved Features Contribute to αβ T Cell Receptor Specificity

✍ Scribed by James P. Scott-Browne; Frances Crawford; Mary H. Young; John W. Kappler; Philippa Marrack; Laurent Gapin


Book ID
116570928
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
834 KB
Volume
35
Category
Article
ISSN
1074-7613

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In B cells the loci encoding immunoglobulin chains usually show allelic exclusion; a given B cell transcribes and translates only one productively rearranged allele of the heavy and light chain loci. This ensures that each B cell expresses only one antigen receptor. The loci encoding T-cell receptor