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Evidence for the presence of antibodies to cholinergic neurons in the serum of patients with Alzheimer's disease

✍ Scribed by P. Foley; H. F. Bradford; M. Docherty; H. Fillit; V. N. Luine; B. McEwen; G. Bucht; B. Winblad; J. Hardy

Publisher: Springer
Year: 1988
Tongue: English
Weight: 638 KB
Volume: 235
Category: Article
ISSN: 0340-5354
DOI: 10.1007/bf00314249

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✦ Synopsis

A blind study showing that serum from patients with Alzheimer's disease causes immunolysis of mammalian brain synaptosomes is reported. Control, aged-matched, sera were largely without effect. The immunolysis was directed mainly against cholinergic synaptosomes. The data presented support the hypothesis that autoimmune mechanisms may operate in the pathogenesis of Alzheimer's disease.

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