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Evidence for the fatty acid-induced heterogeneity of the N and B conformations of human serum albumin

✍ Scribed by Johannes H.M. Dröge; Lambert H.M. Janssen; Jaap Wilting


Book ID
115778275
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
696 KB
Volume
34
Category
Article
ISSN
0006-2952

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Human serum albumin (HSA) is used in large amounts as an excipient in many biopharmaceutical formulation to prevent loss of the active ingredient through adsorption and/or degradation. Traditionally, iso-electric focusing has been used to demonstrate charge heterogeneity in HSA preparations. In an e