Evidence for suppressor cells in Lewis rats' experimental allergic encephalomyelitis
โ Scribed by D.-H. Adda; Evelyne Beraud; R. Depieds
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- English
- Weight
- 398 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Rats of the Fischer 344 (F344) strain are resistant to experimental allergic encephalomyelitis (EAE) induced by active immunization with guinea pig myelin basic protein (MBP) in complete Freund's adjuvant whereas Lewis (LEW) rats are susceptible even though both strains share the same I-A-like class
## Abstract The highly encephalitogenic guinea pig peptide 68โ88 has been used to develop an effective and reproducible model of protection in the Lewis rat. Doses as low as 0.1 nmol of peptide protected 70% of rats when injected intraperitoneally six and four weeks prior to challenge with 0.05 nmo
The idiotype (Id) of T cells and possibly antibodies are involved in an Id network that may immunoregulate experimental allergic encephalomyelitis (EAE). Thus, the adoptive EAE in PL/J mice responding to myelin basic protein (MBP) peptide acetyl 1-9 can be modulated by monoclonal antibody (mAb) anti