Cell-mediated immunity to myelin basic protein in Lewis rats made unresponsive to experimental allergic encephalomyelitis
β Scribed by T. P. McGraw; R. H. Swanborg
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 498 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0014-2980
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## Abstract The highly encephalitogenic guinea pig peptide 68β88 has been used to develop an effective and reproducible model of protection in the Lewis rat. Doses as low as 0.1 nmol of peptide protected 70% of rats when injected intraperitoneally six and four weeks prior to challenge with 0.05 nmo
We have produced T cell lines with a Th2 phenotype in the presence of IL-4 and the glucocorticoid dexamethasone (DEX). IL-4 and DEX together were more effective in inducing a Th2 response than IL-4 alone. Myelin basic protein (MBP)-specific Th2 lines were obtained and their ability to induce experim