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Regulation of experimental allergic encephalomyelitis III. Demonstration of effector cells in tolerant rats

โœ Scribed by James H. Holda; Robert H. Swanborg


Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
329 KB
Volume
11
Category
Article
ISSN
0014-2980

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## Abstract Relatively low numbers of spleen and lymph node cells from Lewis rats previously challenged with myelin basic protein efficiently transfer experimental allergic encephalomyelitis (EAE) to normal syngeneic recipients after __in vitro__ culture with antigen. Moreover, cells obtained from

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Rats of the Fischer 344 (F344) strain are resistant to experimental allergic encephalomyelitis (EAE) induced by active immunization with guinea pig myelin basic protein (MBP) in complete Freund's adjuvant whereas Lewis (LEW) rats are susceptible even though both strains share the same I-A-like class